Centrosome polarization in T cells: a task for formins

Centrosome polarization in T cells: a task for formins

Blog Article

T-cell antigen receptor (TCR) engagement triggers the Sistem distribusi dan cakupan suplementasi tablet besi ibu hamil pascabencana tsunami 2004 di Kabupaten Aceh Besar Provinsi Nanggroe Aceh Darussalam rapid reorientation of the centrosome, which is associated with the secretory machinery, towards the immunological synapse (IS) for polarized protein trafficking.Recent evidence indicates that upon TCR triggering the INF2 formin, together with the formins DIA1 and FMNL1, promotes the formation of a specialized array of stable detyrosinated MTs that breaks the symmetrical organization of the T-cell microtubule (MT) cytoskeleton.The detyrosinated MT array and TCR-induced tyrosine phosphorylation should coincide for centrosome polarization.We propose that the pushing forces produced by the detyrosinated MT array, which modify the position of the centrosome, in concert with Src kinase dependent TCR Ephrin A1 ligand‐based CAR‐T cells for immunotherapy of EphA2‐positive cancer signaling, which provide the reference frame with respect to which the centrosome reorients, result in the repositioning of the centrosome to the IS.